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KMID : 0882420060710010086
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Korean Journal of Medicine
2006 Volume.71 No. 1 p.86 ~ p.90
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Diffuse alveolar damage during chemotherapy with oxaliplatin, 5-fluorouracil and leucovorin
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Lee Kyung-Joo
Jung Ki-Hwan
Choi In-Keun
Kim Je-Hyeong
Seo Jae-Hong
Kim Young-Sik
Shin Chol
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Abstract
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The combination chemotherapy of oxaliplatin with 5-fluorouracil and leucovorin (FOLFOX regimen) has been recently proved to be beneficial in advanced colorectal and gastric cancer. Side effects of this regimen include neutropenia, diarrhea, and neurosensory toxicity. However, the case reports about pulmonary toxicities of this regimen are very limited. Herein is the reported case of a patient treated with oxaliplatin, 5-fluorouracil and leucovorin combination chemotherapy in whom diffuse alveolar damage developed and the disease improved after steroid pulse therapy.
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KEYWORD
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Oxaliplatin, Fluorouracil, Leucovorin, Drug toxicity, Interstitial lung disease
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